:root {
    --peach-50: #fff5f0;
    --peach-100: #ffe8db;
    --peach-200: #ffd4bc;
    --peach-300: #ffb894;
    --peach-400: #ff9466;
    --peach-500: #ff7043;
    --peach-600: #f4511e;
    --peach-700: #e64a19;
    --teal-50: #e0f7f7;
    --teal-100: #b3ecec;
    --teal-200: #80e0e0;
    --teal-300: #4dd4d4;
    --teal-400: #26c9c9;
    --teal-500: #00bfbf;
    --teal-600: #00a8a8;
    --navy-50: #e8f1f5;
    --navy-100: #c5dce6;
    --navy-200: #9fc5d5;
    --navy-300: #78aec4;
    --navy-400: #5b9cb7;
    --navy-500: #3e8baa;
    --navy-600: #2c6b87;
    --navy-700: #1e4d61;
    --navy-800: #12343f;
    --neutral-50: #fafafa;
    --neutral-100: #f5f5f5;
    --neutral-200: #e5e5e5;
    --neutral-300: #d4d4d4;
    --neutral-400: #a3a3a3;
    --neutral-500: #737373;
    --neutral-600: #525252;
    --neutral-700: #404040;
    --neutral-800: #262626;
    --neutral-900: #171717;
}

* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

body {
    font-family: 'DM Sans', -apple-system, BlinkMacSystemFont, sans-serif;
    background: linear-gradient(180deg, var(--peach-50) 0%, var(--neutral-50) 100%);
    color: var(--neutral-800);
    line-height: 1.6;
}

h1, h2, h3, h4, h5, h6 {
    font-family: 'Fraunces', serif;
    font-weight: 700;
    line-height: 1.2;
}

/* Header Navigation */
.header {
    background: rgba(255, 255, 255, 0.95);
    backdrop-filter: blur(10px);
    border-bottom: 2px solid var(--peach-200);
    position: sticky;
    top: 0;
    z-index: 1000;
}

.header-content {
    max-width: 1400px;
    margin: 0 auto;
    padding: 1.5rem 3rem;
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.logo {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    font-family: 'Fraunces', serif;
    font-size: 1.75rem;
    font-weight: 900;
    color: var(--navy-700);
    text-decoration: none;
    transition: transform 0.3s ease;
}

.logo:hover {
    transform: scale(1.05);
}

.logo-emoji {
    font-size: 2rem;
    animation: bounce 2s ease-in-out infinite;
}

@keyframes bounce {
    0%, 100% { transform: translateY(0); }
    50% { transform: translateY(-5px); }
}

.nav-links {
    display: flex;
    gap: 2rem;
    align-items: center;
}

.nav-links a {
    color: var(--navy-600);
    text-decoration: none;
    font-weight: 500;
    font-size: 1rem;
    position: relative;
    padding: 0.5rem 0;
    transition: color 0.3s ease;
}

.nav-links a::after {
    content: '';
    position: absolute;
    bottom: 0;
    left: 0;
    width: 0;
    height: 3px;
    background: linear-gradient(90deg, var(--peach-400), var(--peach-600));
    border-radius: 3px;
    transition: width 0.3s ease;
}

.nav-links a:hover {
    color: var(--peach-600);
}

.nav-links a:hover::after,
.nav-links a.active::after {
    width: 100%;
}

.nav-links a.active {
    color: var(--peach-600);
    font-weight: 700;
}

/* Page Container */
.page-container {
    max-width: 1200px;
    margin: 0 auto;
    padding: 3rem 3rem 5rem;
}

.page-hero {
    text-align: center;
    margin-bottom: 4rem;
    padding: 3rem 2rem;
    background: linear-gradient(135deg, var(--navy-50) 0%, var(--teal-50) 100%);
    border-radius: 24px;
}

.page-hero h1 {
    font-size: 3.5rem;
    color: var(--navy-700);
    margin-bottom: 1rem;
}

.hero-subtitle {
    font-size: 1.5rem;
    color: var(--navy-600);
}

.content-section {
    background: white;
    border-radius: 20px;
    padding: 2.5rem;
    margin-bottom: 2rem;
    box-shadow: 0 4px 20px rgba(0, 0, 0, 0.05);
}

.content-section h2 {
    font-size: 2rem;
    color: var(--navy-700);
    margin-bottom: 1.5rem;
}

.content-section p {
    font-size: 1.125rem;
    color: var(--neutral-700);
    line-height: 1.8;
    margin-bottom: 1rem;
}

.content-section ul {
    margin-left: 2rem;
    margin-bottom: 1rem;
}

.content-section li {
    font-size: 1.125rem;
    color: var(--neutral-700);
    line-height: 1.8;
    margin-bottom: 0.5rem;
}

/* Disclaimer */
.disclaimer {
    background: linear-gradient(135deg, #fef3c7, #fde68a);
    border: 3px solid #fbbf24;
    border-radius: 16px;
    padding: 1.5rem;
    display: flex;
    gap: 1rem;
    align-items: flex-start;
}

.disclaimer-icon {
    width: 24px;
    height: 24px;
    min-width: 24px;
    color: #d97706;
    flex-shrink: 0;
    margin-top: 2px;
}

.disclaimer-content {
    flex: 1;
}

.disclaimer-content h4 {
    font-size: 1rem;
    color: #92400e;
    margin-bottom: 0.5rem;
    font-family: 'DM Sans', sans-serif;
}

.disclaimer-content p {
    color: #78350f;
    line-height: 1.7;
    font-size: 0.9375rem;
}

/* Buttons */
.btn {
    padding: 1rem 2.5rem;
    border-radius: 12px;
    font-size: 1.125rem;
    font-weight: 700;
    text-decoration: none;
    transition: all 0.3s ease;
    font-family: 'Fraunces', serif;
    display: inline-block;
    border: none;
    cursor: pointer;
}

.btn-primary {
    background: linear-gradient(135deg, var(--peach-500), var(--peach-600));
    color: white;
    border: 3px solid var(--peach-700);
    box-shadow: 0 6px 20px rgba(255, 112, 67, 0.3);
}

.btn-primary:hover {
    transform: translateY(-3px);
    box-shadow: 0 10px 30px rgba(255, 112, 67, 0.4);
}

.btn-secondary {
    background: white;
    color: var(--navy-700);
    border: 3px solid var(--navy-300);
}

.btn-secondary:hover {
    background: var(--navy-50);
    border-color: var(--navy-500);
    transform: translateY(-3px);
}

/* Badge Styles */
.card-badge {
    display: inline-block;
    padding: 0.5rem 1rem;
    background: linear-gradient(135deg, var(--peach-100), var(--peach-200));
    border-radius: 8px;
    font-size: 0.8125rem;
    font-weight: 700;
    color: var(--peach-700);
    white-space: nowrap;
    flex-shrink: 0;
}

.stage-badge {
    display: inline-block;
    padding: 0.5rem 1rem;
    background: var(--neutral-100);
    border-radius: 8px;
    font-size: 0.8125rem;
    font-weight: 700;
    color: var(--neutral-700);
}

.nci-badge {
    display: inline-block;
    padding: 0.5rem 1rem;
    background: linear-gradient(135deg, #dcfce7, #bbf7d0);
    border: 2px solid #86efac;
    border-radius: 8px;
    font-size: 0.8125rem;
    font-weight: 700;
    color: #166534;
}

.biomarker-tag {
    display: inline-block;
    padding: 0.5rem 1rem;
    background: linear-gradient(135deg, var(--teal-50), var(--teal-100));
    border: 2px solid var(--teal-300);
    border-radius: 8px;
    font-size: 0.8125rem;
    font-weight: 700;
    color: var(--teal-700);
    white-space: nowrap;
    margin-bottom: 0.5rem;
}

/* Footer */
.footer {
    background: linear-gradient(135deg, var(--navy-700) 0%, var(--navy-800) 100%);
    color: white;
    padding: 3rem 3rem 2rem;
    margin-top: 5rem;
}

.footer-content {
    max-width: 1400px;
    margin: 0 auto;
    display: grid;
    grid-template-columns: 2fr 1fr 1fr;
    gap: 3rem;
    margin-bottom: 2rem;
}

.footer h3 {
    font-size: 1.5rem;
    margin-bottom: 1rem;
    color: var(--peach-200);
}

.footer p {
    color: var(--neutral-300);
    line-height: 1.8;
}

.footer-links {
    list-style: none;
}

.footer-links li {
    margin-bottom: 0.75rem;
}

.footer-links a {
    color: var(--neutral-300);
    text-decoration: none;
    transition: color 0.3s ease;
}

.footer-links a:hover {
    color: var(--peach-300);
}

.footer-bottom {
    max-width: 1400px;
    margin: 0 auto;
    padding-top: 2rem;
    border-top: 1px solid rgba(255, 255, 255, 0.1);
    text-align: center;
    color: var(--neutral-400);
    font-size: 0.9375rem;
}